Please use this identifier to cite or link to this item: http://ir-ithesis.swu.ac.th/dspace/handle/123456789/3621
Title: EFFICACY AND SAFETY OF TOPICAL FINASTERIDE 0.5% SOLUTION ONCE DAILY VERSUS TWICE DAILY IN THE TREATMENT OF MALE ANDROGENETIC ALOPECIA
การศึกษาประสิทธิภาพและความปลอดภัยของยาทายาฟินาสเตอไรด์เข้มข้น 0.5 เปอร์เซ็นต์ ระหว่างการทายาหนึ่งครั้งต่อวันเปรียบเทียบกับการทายาสองครั้งต่อวันในการรักษาภาวะผมบางจากพันธุกรรมในเพศชาย
Authors: CHANTALUCK MUENNARONG
ฉันทลักษณ์ หมื่นณรงค์
Saranya Khunkhet
ศรัญญา คุณเขต
Srinakharinwirot University
Saranya Khunkhet
ศรัญญา คุณเขต
saranyakh@swu.ac.th
saranyakh@swu.ac.th
Keywords: Topical finasteride
male androgenetic alopecia
videodermoscopy
Issue Date:  18
Publisher: Srinakharinwirot University
Abstract: Androgenetic alopecia (AGA) is the most common form of hair loss in men, resulting from progressive miniaturization of hair follicles. While oral finasteride has demonstrated efficacy, its administration may be associated with systemic adverse events. Topical finasteride has been considered as an alternative with a favorable safety profile; however, the optimal frequency of application remains undefined. This study aimed to evaluate and compare the efficacy and safety of topical finasteride 0.5% solution applied once daily versus twice daily in the treatment of male AGA. A 24-week randomized, investigator-blinded trial was conducted involving 60 male participants aged 22 to 60 years with a clinical diagnosis of mild to moderate androgenetic alopecia (AGA). Participants were randomly assigned to receive either once-daily or twice-daily application of topical finasteride 0.5% solution. Primary outcomes included changes in total hair density, terminal hair density, and non-terminal hair density. Secondary outcomes included changes in hair diameter, global photographic assessment (GPA), patient satisfaction, and the incidence of adverse events. Both regimens resulted in statistically significant improvements in all measured hair parameters compared to baseline (all p < 0.05). The twice-daily application demonstrated significantly greater increases in the mean change of total hair density (p = 0.036) and non-terminal hair density (p = 0.044) compared to the once-daily regimen. Improvements in terminal hair density and hair diameter were observed in both groups, with no significant differences in the mean changes between them. GPA scores were higher in the twice-daily group, indicating a trend toward greater visual improvement. Patient satisfaction was high in both groups, with a slight preference for the twice-daily regimen. No systemic adverse events were reported, and only mild local reactions were observed. Topical finasteride 0.5% solution is effective and well tolerated for the treatment of male androgenetic alopecia (AGA). The twice-daily regimen provides superior improvements in total and non-terminal hair density, thereby enhancing overall treatment outcomes and rendering it appropriate for patients aiming to achieve maximal therapeutic benefit. In contrast, the once-daily application remains a convenient and effective alternative with a comparable safety profile. These findings support the use of topical finasteride as a treatment option with minimal risk of systemic side effects.
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URI: http://ir-ithesis.swu.ac.th/dspace/handle/123456789/3621
Appears in Collections:Faculty of Medicine

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