ASSOCIATION OF GUT MICROBIOTA WITH DYSLIPIDEMIAAND CHRONIC CORONARY SYNDROME PATIENTSUNDERGOING CORONARY ANGIOGRAPHY

Abstract

Dyslipidemia is a significant risk factor for chronic coronary syndrome (CCS), which has a high death rate. Dysbiosis of the gut microbiota, its metabolites, and inflammation have an impact on atherosclerosis, which is the etiology of CCS. The objective was to compare the gut microbiota composition and diversity among CCS patients undergoing coronary angiography and dyslipidemia patients to healthy volunteers in Thailand, as well as to examine the clinical characteristics associated with these conditions. A total of 91 patients met the inclusion criteria. According to our findings, CCS patients exhibited higher risk factors, inflammatory markers, and high-sensitivity C-reactive protein (hs-CRP) than others. We demonstrated that compared to the healthy group, patients with CCS and dyslipidemia had reduced alpha diversity. The gut microbiota compositions of three groups differed significantly. In CCS patients, there was a significant rise in the relative abundance of Proteobacteria, Fusobacteria, Enterobacteriaceae, Prevotella, and Streptococcus, but a decrease in Roseburia, Ruminococcus, and Faecalibacterium. Lachnospiraceae, Peptostreptococcaceae, and Pediococcus showed favorable correlations with hs-CRP in CCS patients. The genera Sutterella and Roseburia showed a negative correlation with low-density lipoprotein cholesterol (LDL-C) in CCS patients. Megasphaera showed a substantial positive correlation with triglyceride (TG) levels in patients with dyslipidemia, but it showed a negative correlation with high-density lipoprotein cholesterol (HDL-C). The changes in clinical factors linked to the onset of coronary artery disease (CAD) in CCS patients were linked to altered gut microbiota. Pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) have an important role in the process of atherosclerosis. Moreover, gut microbiota dysbiosis can lead to leaky gut syndrome, subsequently triggering abnormal immune responses and contributing to several diseases, including atherosclerosis and CAD.-